The Great Smoky Mountains National Park is the most visited park each year - and it's not even close. Nearly double the amount of people visit the Smokys compared to the 2nd most visited park (Grand Canyon National Park (worldatlas.com)). In a geographically-centered location (a bridge between the Midwest and South), the Smokys provide visitors a simpler and Appalachian experience.
Get Comfy: Strawberry Patch Inn - There are 2 main entrances to the Smokys. The one that you've probably heard of is Gatlinburg. While popular and worth visiting, Gatlinburg isn't quaint. If you are more into a slower pace, and ok with less options, then you should stay in Townsend, Tennessee, which is self-proclaimed as the "quiet side of the Smokys". The Strawberry Patch Inn sits right on the Little River and is close to a handful of restaurants.
Wildlife - The Smokys are notorious for black bears (both in the woods and even in town). Be mindful of these creatures while hiking. Be respectful of their space, and do your homework before visiting. Consider bear bells, canisters, spray, etc. If you want to see a bear from the safety of your car, try checking out Cade's Cove - they are known to be seen quite frequently in this area.
Gram-Worthy: Clingmans Dome - It'll take you a minute to get here. Although relatively short in distance, the curvy roads, coupled with the want to pull over ever other minute to take in the views will make the drive about the journey and not the destination. Waiting at the top of the drive is Clingmans Dome. Park in the parking lot, and take the paved trail to the top. Your reward is 360-degrees of unobstructed Smoky Mountains. You see into both North Carolina and Tennessee, as it sits on the border. Be mindful on this drive - the mountains have their own climate. Dense fog and/or precipitation can appear seemingly out of nowhere.
Get Moving: Chimney Tops Trail - The trail is sure to get your heart rate up. The trail head starts from a parking lot on the side of the road that leads to Clingmans Dome. Starting low and along a babbling creek, the hike quickly and drastically ascends up the mountain. There are a lot of stairs on this hike - only take this trail if you're up to the challenge. Due to recent fires, the summit prematurely ends (about 75% of the original trail) - but it's still worth the trek!
Soul Recharge: Any stop on the way to Clingmans - You will encounter several pull-off parking spots along the drive to Clingmans Dome - take advantage of these! It will be tempting to want to continue on to the top, but do yourself a favor and take in the view from a pull-off spot. It can be dangerous to drive and look, so take a break and treat yourself to an incredible view!